Clik here to view.
Evolution at Two Levels: On Genes and Form
Evolution at 2 Levels: Genes & Formhttp://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.0030245 Reg evol likely for genes in mult tissues, w. pleiotropic coding SNPs & mult...
View ArticleClik here to view.
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription...
Circadian #Enhancers Coordinate… Rhythmic… Transcription http://www.cell.com/cell/abstract/S0092-8674%2814%2901310-5 Periodicity helps find #eRNAs/enhancers & their targets
View ArticleClik here to view.
Extensive evolutionary changes in regulatory element activity during human...
Changes in [DHS] #regulatory element activity…[over 3 primates] associated w/ altered…expression & pos. selection http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002789 DHS...
View ArticleClik here to view.
Unraveling determinants of transcription factor binding outside the core...
Segal cites: Determinants of TF binding outside the core binding site http://genome.cshlp.org/content/early/2015/06/05/gr.185033.114.abstract Large-scale measurement of affinity #ICSG2015
View ArticleClik here to view.
Inferring gene regulatory logic from high-throughput measurements of...
Segal cites: Measurements of 1000s of…designed promoters http://www.nature.com/nbt/journal/v30/n6/full/nbt.2205.html Num. binding sites correlated w/ expr., for 1st few #ICSG2015
View ArticleClik here to view.
Enhancer Evolution across 20 Mammalian Species: Cell
#Enhancer Evolution across 20 Mammal[s is faster than for promoters] by @PaulFlicek lab http://www.cell.com/cell/abstract/S0092-8674(15)00007-0 H3K27ac & H3K4me3 #chipseq...
View ArticleClik here to view.
promoter/enhancer categorization and Encyclopedia
Genome-wide characterization of..promoters w…enhancer functions http://www.Nature.com/ng/journal/v49/n7/full/ng.3884.html Blurs distinction betw these, suggests flexibility Genome-wide characterization...
View ArticleSequence of events in prostate cancer
Sequence of events in prostate #cancer, by @MarkARubin1 http://www.Nature.com/articles/d41586-018-06029-5 Discusses the high prevalence of AR-enhancer amplifications in recent studies QT:{{” “Quigley...
View Article